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Pickart proposed that this activity in human plasma albumin was a tripeptide glycyl-L-histidyl-L-lysine and that it might function by chelating metal ions

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Furthermore, it has been shown that co-treatment of EOC cells with cisplatin and bortezomib produced more pronounced effect on cell proliferation, apoptosis and S-phase kinase protein 2 (SKP2) down-regulation causing accumulation of p27kip1which is a cyclin-dependent kinase inhibitor [53]

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For instance, methotrexate, the cornerstone DMARD, provides clinical benefit in just 30 - 40% of patients and is associated with hepatic toxicity in 10 - 0% (8)