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An accumulation of lactate to dangerous levels ( lactic acidosis ) can occur when metformin is taken by patients with other conditions resulting metabolic acidosis (liver disease, heart failure, sepsis, alcohol abuse), or kidney disease (as indicated by elevated creatinine levels) because metformin is eliminated by renal excretion) (He & Wondisford, 2015

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erinaceus extracts have also shown to exert beneficial effects in a number of pathological conditions due to its anti-inflammatory properties (7, 8)

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Mechanistically, SQOR preserves intestinal homeostasis through two major pathways: it inhibits Drp1-mediated mitochondrial fission, thereby reducing ROS accumulation, and it activates the PGC1 pathway to promote mitochondrial biogenesis and antioxidant defenses (upregulating enzymes like GPX4 and SOD2)