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An October 2016 article in the Journal of Chemical Education points out there is commercially available hydrogen chloride (HCl) with a pH of -1.1, sodium hydroxide (NaOH) with a pH of 15, and even hot springs around Russias Ebeko Volo with a pH of -1.7

2023;7(S2):14-15.

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Cartilage and joint repair models: Intraarticular injection of AOD9604 in a collagenase induced rabbit osteoarthritis model showed improved cartilage architecture and regeneration