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Le glutathion s'oxyde rapidement - surtout sous sa forme rduite

In xenografts, luteolin (100 mg/kg IV) reduced tumor burden and prolonged survival without systemic toxicity, supporting its potential as a safe adjunct targeting tumor stemness ( In Ca Ski cervical cancer cells, luteolin (25100 M) inhibited proliferation and induced intrinsic apoptosis characterized by caspase activation and mitochondrial dysfunction ( Transcriptomic analyses indicate that luteolin targets genes involved in IL-17 signaling, oxidative stress regulation, and homologous recombination repair (Zhao et al., 2023)

Supplementary Figure 4 a, Heatmaps showing combination interactions between inhibitors of the glutathione and thioredoxin pathways

Furthermore, Aldehyde dehydrogenase 1A3 (ALDH1A3) was observed to promote the tetramerization of PKM2, which facilitates lactate-induced lactylation of X-ray cross-complementing protein 1 (XRCC1) at the K247 site, directly leading to a diminished response of tumor cells to TMZ and radiation therapy

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