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In silico molecular docking studies have shown that resveratrol forms critical hydrogen bonds within the ER binding site, thereby stabilizing the receptorligand complex and mimicking the binding conformation of E2

1 Introduction 1.1 Clinical characteristics and therapeutic limitations of Parkinsons disease Parkinsons disease (PD) is the second most prevalent neurodegenerative disorder worldwide, characterized clinically by resting tremor, bradykinesia, rigidity of the limbs and trunk, and postural instability (1)