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Moreover, JHU083 modulates MDSCs within the TME, promoting their polarization into pro-inflammatory TAMs and inhibiting the expression of IDO, thereby boosting the anti-tumor immune response [147]

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Maintain the supporting factors that affect outcomes

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4.1 Iron chelators Iron chelator has the ability to become a stable complex through strong binding with iron ion, thus preventing too much free iron ion from participating in redox reaction in cells to produce ROS, initiate lipid peroxidation, cause cell oxidative damage and trigger ferroptosis