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Consistently, they reduce DHA into ascorbate with a better efficiency ( k cat around 10 4 s 1 , k cat / K m around 10 7 M 1 .s 1 ) compared to the other enzymes ( k cat around 10 2 s 1 ) and to the reduction of glutathionylated-mercaptoethanol, the product formed upon incubation between GSH and HED ( k cat around 10 2 s 1 ) (Table 5) (Dixon et al., 2003)

Nat Rev Neurosci 10(1):2336 Canta A, Pozzi E, Carozzi VA (2015) Mitochondrial dysfunction in Chemotherapy-Induced Peripheral Neuropathy (CIPN)

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