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During acute illness, direct consequences of viral reactivation or infection are thought to occur in localised areas such as the brain and neuronal cells, muscle cells, and cardiac myocytes [Extended Figure 8 in (127)]

Significant gaps exist in platform and regulation: head-to-head platform trials are absent, and the use of adaptive designs is only 3%

A large-scale, three-part study involving 11,420 males in the US found PD prevalence rates as high as 13%

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