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One way to correct for confounding is stratification

Kouzegaran S, Zamani MA, Faridhosseini R, Rafatpanah H, Rezaee A, Yousefzadeh H, et al

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In normoxia, hydroxylation of HIF- by PHDs enables its interaction with pVHL (von Hippel-Lindau protein) and targets subunits for ubiquitination and proteasomal degradation [140]