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Specific Adverse Effects Reported in Clinical Trials While the overall safety profile was excellent, clinical trials documented all adverse events regardless of severity or causality

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Quality Control Regulatory compliant, in-house, QC labs support all clinical and commercial GMP sites pre- and post-production, ensuring top-quality testing for products and oversight of other critical functions (e.g., environmental monitoring, cleaning validations, instrument life-cycle and sample/retain management and audits)

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The group of Chavkin showed that rKOR is phosphorylated in vivo at S369 by GRK3 upon U50,488 exposure (Mclaughlin et al., 2004) and in vitro by GRK2 (Mclaughlin et al., 2003)