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38,39 These failures may be attributed in part to flaws in study design, such as imbalance in patient baseline across treatment arms and lack of specific participant eligibility criteria, but may also be due to the structure of the agents themselves being less active in humans and presenting off-target toxicity

Golab, F

N-acetylcysteine supplementation improves endocrine-metabolism profiles and ovulation induction efficacy in polycystic ovary syndrome

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This compound demonstrated excellent properties in preclinical studies: its inhibitory activity against P2Y14R (IC 50 = 5.6 nM) surpassed that of the lead compound PPTN, with more favorable pharmacokinetic characteristics (Ma et al., 2025)