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The molecular mechanisms underlying the ACEI/ARB-induced suppression of DPN development accompanying T2DM in the clinical and preclinical studies are still open to question

Angiogenesis is a critical process in the development of new blood vessels, and preventing or slowing their growth can benefit various disorders

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Regarding the affinity of the fluoro compound 27 , it was anticipated that the hydroxyl group of the tyrosine side chain of 25 makes a hydrogen-bond with Glu494 of IRAP, an interaction that is lost in the case of 27 according to the free energy perturbation (FEP) analysis (Jespers et al., 2019), explaining the reduction in binding affinity of compound 27 as compared to the analogous compound 25