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The mean climate of the Community Atmosphere Model (CAM4) in forced SST and fully coupled experiments

Cloning, protein expression and purification N terminal His 6 -tagged hsDDB1 BPB (UniProt: Q16531, aa396705 replaced with a GNGNSG linker) and FLAG-tagged hsCRBN (UniProt: Q96SW2) were cloned into pAC8-derived vectors 133

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For Mitochondrial membrane potential (MMP) analysis, the cells were stained by 5,5,6,6-tetrachloro-1,1,3,3-tetraethylbenzimidazolocarbocyanine iodide (JC-1) (5 g/mL) for 20 min and then washed with PBS for three times

Peptide MHC binding prediction Peptide binding predictions were performed by using NetMHCpan 4.1 31