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Studies have shown that serum levels of TNF- are significantly elevated in patients with CD and UC, with levels closely associated with disease activity, suggesting that TNF- is a key driver of the inflammatory response in IBD [290]

For instance, derivatives of the ROS-generator 2-Methoxyestradiol (2-ME) potently inhibit store-operated Ca 2+ entry (SOCE) in T cells, effectively dampening T-cell activation and cytokine production [319]

Volek JS, Fernandez ML, Feinman RD, Phinney SD

Ishaq HM, Mohammad IS, Guo H, Shahzad M, Hou YJ, Ma C et al (2017) Molecular estimation of alteration in intestinal microbial composition in Hashimotos thyroiditis patients

doi:10.3233/JAD-142499 25 Hauer, K., Hildebrandt, W., Sehl, Y., Edler, L., Oster, P