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It does not override poor sleep, sedentary habits, or a diet that defeats its metabolic effects

This selective action has made it a significant area of research for metabolic disorders, particularly those related to obesity and fat metabolism, without the broader endocrine impacts associated with intact growth hormone

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Populations at a higher risk of vitamin B12 deficiency include people who are vegetarian or vegan, exclusively breastfed infants of vegan women, older adults, those with gastrointestinal disorders or who have had gastrointestinal surgery, and people with an autoimmune condition known as pernicious anemia

It is widely used in biochemical research as a selective, substrate-competitive inhibitor of nicotinamide N-methyltransferase (NNMT)