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These compounds are characterized by their low toxicity and limited interactions with conventional drugs

Further work is required to elucidate the significance of DHAR activity and to clarify discrepancies between modelled and experimental data

While it effectively bypasses digestion, it introduces higher costs and safety risks compared to oral or topical alternatives

WNT9A has been identified as a potential novel pathogenic gene that may be involved in the pathogenic mechanisms of OA

A large number of clinical samples and animal experiments show that GPX4 levels are significantly decreased in degenerative cartilage tissue, and the degree of its downregulation correlates with the severity of articular cartilage destruction, matrix degradation, and inflammation (Miao et al., 2022