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doi: 10.1038/s41598-017-01387-y 99 YangP.LiX.YangW.HeL.YangL.ZhangX

Sample Size Estimation and Statistical Analysis On the basis of preliminary data in nondiabetic subjects with insulin resistance [14], SBP in eligible patients was expected to average 142.2 16.3 mm Hg at baseline and decrease by 10 mm Hg at study end in those randomized to ALC

The mechanism underlying carnitine's anti-aging effects involves multiple pathways: restoration of mitochondrial cardiolipin content and membrane integrity, enhancement of fatty acid oxidation to reduce lipotoxic stress, reduction of protein oxidation and carbonyl formation, improvement of calcium homeostasis and cellular signaling, and activation of stress resistance pathways that promote cellular resilience