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In addition, PI3K/Akt is upstream of Nrf2, a transcription factor for generating antioxidative enzymes

J.KornbluthA.RachmilewitzD.et al (2010)

& Mukhopadhyay, S

57 In the United States, Australia and New Zealand, a more conservative measurement has been established, starting at a 4-hour APAP concentration of 150 g/mL and known as the treatment line, which is intentionally set lower to account for inaccuracies in the history of APAP ingestion and inherent laboratory error in APAP measurement