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Under nutrient-abundant conditions, it phosphorylates ULK1 to suppress mitophagy, whereas under nutrient-limited conditions, mTORC1 is inactivated, allowing AMPK to activate ULK1 by phosphorylation, thereby inducing mitophagy (97)

10.1016/j.gie.2017.05.036 13 AlonsoJ.PetukhovaM.VilagutG.ChatterjiS.HeeringaS.stnT

The core objective of these strategies is to address the complex, multi-system pathological mechanisms of PD, aiming to achieve superior overall efficacy compared to single-target therapies through synergistic interventions at different pathological nodes