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Two molecular pathways initiate mitochondria-dependent dopaminergic neurodegeneration in experimental Parkinsons disease

doi: 10.3389/fendo.2023.1332114 Received 02 November 2023 Accepted 04 December 2023 Published 24 January 2024 Volume 14 - 2023 Edited by Stefano Zucchini, IRCCS University Hospital of Bologna Sant Orsola Polyclinic, Italy Reviewed by Cristina Partenope, Azienda Ospedaliero Universitaria Maggiore della Carit, Italy David Ingram, Childrens Mercy Kansas City, United States Updates Copyright 2024 Zaffanello, Pietrobelli, Cavarzere, Guzzo and Antoniazzi

In the context of pyroptosis, studies have confirmed that pathological Tau can upregulate the NLRP3/caspase-1/GSDMD pathway, thereby promoting the induction of pyroptosis [152]