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1 H NMR (400 MHz, DMSO- d 6 ) was shown in Supplementary Fig

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Exploratory subgroup analysis revealed that individuals with mild obesity, low insulin resistance, and reduced insulin secretionclassified as mild age-related diabetes (MARD)exhibited a more pronounced glucose-lowering response, with a mean reduction of 0.4 mmol/L (p=0.008)

4 Drugs related to the Nrf2 pathway With the further clarification of the molecular mechanism for the regulation of Nrf2/ARE signaling pathway and its pathophysiological significance, drug development based on this pathway has attracted more and more attention