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NAFLD alleviating potential of black cumin oil has also been studied in a randomized, double-blind, placebo-controlled clinical trial, which demonstrates a reduction in FBS level, lipid profiles (TG, TC, LDL, VLDL), liver enzymes (AST and ALT), hs-CRP inflammatory marker, IL-6, TNF-, and an increase in the HDL-C levels in the interventional group compared to the placebo group [163]

doi: 10.1002/advs.201903035

doi: 10.1517/14656566.8.12.1821

doi: 10.3389/fcimb.2025.1733264 Received 30 October 2025 Revised 25 November 2025 Accepted 29 November 2025 Published 16 December 2025 Volume 15 - 2025 Edited by Akansha Singh, University of Texas Southwestern Medical Center, United States Reviewed by Cristin Coman, National Institute of Medical-Military Research and Development, Romania Rahul Ahuja, University of Colorado, United States Updates Copyright 2025 Resta, Tal, Conte, Calcagnile, Bucci and Alifano

Patients with IPF often present with progressive dyspnea, and lung function continues to deteriorate