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Thus, the DEGs related to GSH metabolism suggest that the biosynthesis and recycling of GSH are critical for both HL and R processes (Figure 2)

Mitochondrial Respiration and Hypoxia Protection The 2003 study by Khvatova, Samartzev, Zagoskin, Prudchenko, and Mikhaleva published in Peptides confirmed that DSIP significantly increased ADP-stimulated mitochondrial respiration in rat brain mitochondria under experimental hypoxia conditions establishing a direct mitochondrial respiratory mechanism for DSIPs stress-protective potency and linking DSIP biology to the emerging field of mitochondria-targeted neuroprotective peptides

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93 In addition, the upregulation of GLUT-4 and adenosine monophosphate-activated protein kinase (AMPK) reduces IR