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doi: 10.1167/iovs.04-0753

The most intriguing and at the same time explanatory example comes from cancerous cells treated with ROS or with thiol-oxidizing agents

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Using distinct HIF-1 antibodies for staining macrophages, dual-positive immunofluorescence for HIF-1 + and CD206 + macrophages was detected in proximity to capillaries (186), indicating that vascular neogenesis in jDM patients is regulated by the VEGF/HIF pathway, inducing HIF-1 and promoting CD206 expression in macrophages, which may lead to hypoxic damage to capillaries in DM patients