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cardiovascular disease, neurodegenerative disorders, rheumatoid arthritis, chronic kidney disease, and some cancers [17,18,19,20,21,22,23], leads to a pathology associated with accumulation of misfolded proteins in the affected tissue

Stieb S, Mohamed ASR, Deshpande TS, Harp J, Greiner B, Garden AS, Goepfert RP, Cardoso R, Ferrarotto R, Phan J, Reddy JP, Morrison WH, Rosenthal DI , Frank SJ, Fuller CD, Brandon Gunn G, Head MD, Working Group NCS

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revealed that high expression of ACLY was associated with poor overall survival in HNSCC patients who received radiotherapy [127], and inhibition ACLY expression caused an impairment of DNA damage repair, leading to radiosensitization in HNSCC cell lines [127]