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It even worsened the symptoms of nerve damage after 6 months of treatment [28]

Furthermore, phase II studies were undertaken to prove the efficacy of mecasermin rinfabate (IGF-1/IGFBP-3) in paediatric severe burns and had promising outcomes when doses of 14 mg/kg/day [269273] were used

Clinically, the ability of cobalt to induce delayed hypersensitivity is well known for contact dermatitis (Cirla, 1994)

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