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Concurrently, insulin resistance, chronic inflammation, and obesity contribute to ROS overproduction, while the activity of antioxidant enzymes (such as superoxide dismutase and glutathione peroxidase) are significantly reduced ( In PCOS, excessive ROS inflict damage on oocytes and granulosa cells, disrupt the follicular microenvironment, and impair follicular development and ovulation ( e.g ., CYP17) in ovarian theca cells, exacerbating hyperandrogenemia ( e.g ., vitamin C, vitamin E, N-acetylcysteine) may mitigate oxidative damage, improve insulin sensitivity, and restore ovarian function by neutralizing ROS ( 3.2 Autophagy Autophagy is a fundamental cellular process responsible for degrading and recycling damaged organelles and proteins, playing a critical role in maintaining cellular homeostasis

In HSCs, sirtuin 3 (SIRT3) preserves genomic stability and mitochondrial integrity, delaying cellular aging by increasing superoxide dismutase 2 (SOD2) activity and reducing oxidative stress

Barman D, Dey N, Sen S, Kakoti B, Vanlalhriatpuii C (2022) Neuromodulatory effect of plant metabolites

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Step 1: Choose a High-Bioavailability Format Look for "liposomal" on the label