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Body specific substance It is not an essential nutrient because our body can make it itself from its constituent substances

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Acknowledgements The authors appreciate and thank the efforts of the Center for the Development of Clinical Researches of the Educational and Therapeutic Research Complex of Birjand University of Medical Sciences

However, our data suggest several potential paths forward: both Osimertinib and CP-24 sensitize GBM cells to temozolomide and radiotherapy, downregulate DNA repair pathways, and reduce PD-1 protein levels, raising the prospect of rational combinations with standard-of-care treatments and/or immune checkpoint blockade