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However, while current findings are encouraging, more rigorous clinical trials are essential to confirm their efficacy, determine optimal dosages, and assess long-term safety profiles

Interestingly, a recent study showed that despite the low plasma concentration of polyphenols, polyphenols were transported to the arterial intima at pH 7.4 in the form of bound lipoproteins, and polyphenol levels were significantly elevated in endothelial cells and macrophages (148)

Zhang H, Yue X, Chen Z, Liu C, Wu W, Zhang N, et al

Bile acids as metabolic regulators and nutrient sensors

A more reliable technique is to reduce (knockdown) expression of the gene product, which can be achieved with RNA interference therapies that use a cells own machinery for regulating protein expression or with antisense oligonucleotides (ASO)