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de Oliveira B, Oliveira BC, Deutsch G, Pessanha FS, Thire R, de Castilho SR

At the molecular level, this process is driven by metabolic reprogramming from hepatocyte lipid overload: excessive free fatty acids (FFAs) undergo esterification mediated by Acyl-CoA Synthetase Long-Chain Family Member 1 (ACSL1) , producing toxic lipid intermediates (e.g., diacylglycerol, ceramide) 48 , These intermediates disrupt hepatic lipid homeostasis, causing compensatory dysregulation of mitochondrial -oxidation and peroxisomal lipolysis

Charugulla (2021) Efficacy and safety comparison of combination of 0.04% tretinoin microspheres plus 1% clindamycin versus their monotherapy in patients with acne vulgaris: a phase 3, randomized, double-blind study, Journal of Dermatological Treatment, 32:8, 925-933, DOI: 10.1080/09546634.2020.1720579 Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ

As referred, the decomposition of H 2 O 2 is particularly important in erythrocytes, to prevent oxidation of Hb and of other RBC constituents

While most studies have focused only on the topographical features of the grafts, we have considered both the biophysical and biochemical manipulations in our applied nanoscaffold