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Hyperpigmentation related to B12 deficiency can be a significant concern for those affected, as it may indicate an underlying nutritional issue that needs to be addressed. Health Professional The skin may also appear pale or yellowish due to anemia caused by the deficiency

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ACIP and CDC recommend individual decision-making (also known as shared clinical decision-making) after a discussion with a healthcare professional (nurse, doctor, or pharmacist) for people age 6 months and older who are moderately or severely immunocompromised