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The study was carried out in 112 subjects with moderately severe CTS, comparing the effectiveness of a multivitamin B preparation (Vit B6 150 mg, Vit B1 100 mg, Vit B12 500 g daily) for 90 days with a fixed association of ALA (600 mg/day) and gamma-linolenic acid (GLA, 360 mg/day)

This problem not only hinders the interpretability of algorithms but may also result in negative consequences, such as algorithmic collusion or abuse of power

[1] [4] Published phase 2 trial data (Jastreboff et al., NEJM , 2023) reported dose ranges from 1 mg up to 12 mg weekly, with higher doses associated with greater weight loss but also increased rates of gastrointestinal side effects