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In a previous report, Kudo and colleagues demonstrated that only meningiomas exhibit extremely high GSH levels, in contrast to other forms of brain tumors, such as GBM, gliomas, germinoma, multiple myeloma, and small-cell carcinoma [45]

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Both mouse primary cortical neurons (10 or 20 M for 3 or 6 h) and a triple-transgenic AD mouse model treated with SF (56.4 or 282 mol/kg/day for 6 days/week for 8 weeks) exhibited enhanced brain-derived neurotropic factor (BDNF) expression, crucial for neuronal survival and synaptic plasticity, suggesting a potential epigenetic mechanism for SFs neuroprotective effects (61)

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