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While, similar to blood cytokine studies, comparing levels of a limited number of cytokines with healthy controls has not given a consistent picture (Lloyd et al., 1991

doi: 10.1016/j.jbc.2022.101747 333 ZhangJLinWTangMZhaoYZhangKWangXet al

However, vitamin B12 supports several processes in your body that can indirectly help with weight management: Boosts energy levels, potentially increasing motivation for physical activity Helps metabolize fats and proteins, supporting overall metabolism May improve mood and reduce stress, which can prevent emotional eating Supports the production of red blood cells, enhancing oxygen delivery to muscles during exercise Could help regulate sleep patterns, as poor sleep is linked to weight gain Might reduce appetite in some individuals, leading to decreased calorie intake When combined with a balanced diet and regular exercise, may enhance the effectiveness of weight loss efforts Risks and Side Effects While B12 shots for weight loss are generally safe, it's important to know about potential side effects

Clinical research has suggested that the levels of FOXO proteins in the central nervous system may be altered in research models of neurodegenerative disorders (NDDs)

doi: 10.3389/fendo.2019.00510 169 SabatinoL