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At DIV7, the neurons were infected with AAV1/2-GFP-U6-shTNR (shRNA for TNR) or AAV1/2-GFP-U6-shScr (scramble shRNA) (1 l/ml with a titer of 3.35 10 10 )

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This imbalance can lead to oxidative-mediated central nervous system (CNS) damage, which is further supported by declined cognitive abilities and more severe depressive symptoms in these individuals