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The results confirmed that Tbx1 +/ and Df1 / + brains have increased concentrations of MMA compared with WT controls (all animals were PBS-treated), and they showed that although vB12 treatment had no impact on MMA in WT animals, it was restored to WT levels in both of these mutants (Fig 3)

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In diet-induced obesity animal models, NNMT inhibition demonstrated metabolic changes including alterations in adipocyte lipid content without affecting food intake patterns, coupled with significant reductions in white adipose tissue mass in treated mice

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