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Pharmacological therapies targeting GPX4 are a promising strategy for inducing ferroptosis in cancer cells, including clear-cell carcinomas that resistant to conventional treatments [49]

The discovery of G6PD crystal structures and subsequent analyses provided us with further insights into this enzyme deficiency, since specific mutations can now be plotted on a 3D position in the protein structure

S1b and Supplementary Fig

p-IRS-1: phosphorylated insulin receptor substrate