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Freeze drying (FD) achieves high-quality products by sublimating water directly from the solid to vapor phase, maintaining heat-sensitive properties like vitamins due to the low drying temperature (92)

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Parallel modulators such as brain-derived neurotrophic factor (BDNF) ( via tropomyosin receptor kinase B (TrkB)/AKT) and g protein-coupled receptor kinase 2 (GRK2) [which constrains p38-mitogen activated protein kinase (MAPK)] fine-tune the pathway in neural tissue, while AMPK provides an energy-status override that can suppress mTORC1 even when PI3K is active (Zhang HP

doi: 10.1172/JCI134778 279 BriardBKarkiRMalireddiRKSBhattacharyaAPlaceDEMavuluriJet al