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Whilst not reaching the maintenance dose of Wegovy could be considered as an off license use of the medication, under the appropriate qualified supervision a medical judgement can be made on the appropriateness of continuation of treatment on a lower dose

Clinical trials used doses of 0.3 4.5 mg/week, at a 2.5 mg/ml concentration, a 2.4 mg dose = 0.96 ml = 96 IU on the insulin syringe

However, the review rated the overall evidence quality as very low due to small sample sizes, short follow-up periods, high risk of bias, and predominantly manufacturer-funded studies

CNS Neurosci Ther 31:e70511

Most preclinical studies utilize supraphysiologic doses, alternate routes of administration and short follow-up windows that do not mimic human reproductive timelines