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This paper establishes mitochondrial membrane potential as the key determinant of PINK1 import and PARL-mediated cleavage, providing the foundational mechanistic link between mitochondrial dysfunction and activation of PINK1Parkin mitophagy signaling

Jacque N, Ronchetti AM, Larrue C, Meunier G, Birsen R, Willems L, Saland E, Decroocq J, Maciel TT, Lambert M, Poulain L, Hospital MA, Sujobert P, Joseph L, Chapuis N, Lacombe C, Moura IC, Demo S, Sarry JE, Recher C, Mayeux P, Tamburini J, Bouscary D

, , and were the traditional vegetables identified which are rich in methionine and , , sp., , and and rich in cysteine

Immunofluorescence intensity was quantified and analyzed using ZEN Lite 2011 and Image J software

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