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In SLE, nutritional therapy, which involves limiting the protein and carbohydrate intake as well as using nutritional supplements (such as vitamins, minerals, and polyphenols), is often considered a potential approach to managing inflammatory reactions ( 5.4 Application of immunomodulators Reducing the severity and maintenance of tissue homeostasis is the major goal in the treatment of SLE patients using various biological agents, immunosuppressants, glucocorticoids, etc

Similar ischemia-induced upregulation of TRPM7 was subsequently observed in rat brain tissues (Zhan et al., 2014

To maximize and analyze differences among the five groups, partial least square-discriminant analysis (PLS-DA) was also performed