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Description

Chorioamnionitis and early lung inflammation in infants in whom bronchopulmonary dysplasia develops

Kammona O, Kiparissides C

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Under the excessive accumulation of reactive oxygen species (ROS), over-oxidized PUFA-containing phospholipids (PUFA-PLs) alter the membrane structure and increase its permeability, eventually leading to plasma membrane rupture and cell damage [8]

In addition, the vast majority of current available HDACi are hydrophilic substances and the blood-brain barrier (BBB) prevents these compounds from entering the brain to exert therapeutic potential