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If the bioregulator framework is correct (peptide triggers a cascade that persists after clearance), pulsed dosing should theoretically work though its been studied less than the daily protocols

doi:10.1111/andr.12025

A., Tavare, A., DeProto, J

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iHLOs model for toxicology applications To evaluate iHLOs as a model for toxicology studies, we compared proteomic profiles of Day 30 iHLOs, PHHs, HepG2 cells, and HepaRG cells against human liver tissue