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Most of the compounds produced an anti-inflammatory response superior to the indomethacin control, reaching a concentration necessary for 50% inhibition of 0.45 g/ml for superoxide anion generation, and 1.68 g/ml for elastase release

Together these results establish 4HNE as the biological ligand for GDAP1, provide mechanistic insight into 4HNE binding, and demonstrate that altered 4HNE recognition is the likely mechanism underlying CMT-causing mutants such as T157P near the 4HNE binding site

Optimal exposure windows, dose scheduling, and the potential for hormetic effects or long-term consequences are poorly defined, impeding the rational design of exercise mimetic administration strategies

Anemia and red blood cell transfusions, cerebral oxygenation, brain injury and development, and neurodevelopmental outcome in preterm infants: a systematic review

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