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FEBS J 275(15):39593970

doi: 10.2174/1570163817666200518074629 404 RochaOBe SilvaKSFde Carvalho JuniorMABMoraesDAlonsoAAlonsoLet al

Common examples of treatment include retinoids, antibiotics, antibacterial agents, and comedolytic agents

Such changes can increase gut permeability (leaky gut) and expose the mucosal immune system to bacterial products, thereby activating immune pathways that target distant tissues (Fig