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Moreover, exogenous acetate was observed to reverse CIA mice with exacerbated gut microbial disruption, thereby further confirming the crucial role of the effect of gut microbial metabolite acetate on neutrophils in vivo in immune regulation (Jin et al., 2023

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doi: 10.1016/j.biochi.2022.08.008, 232

Intestinal mucosal barrier The dysbiosis of gut microbiota and gastrointestinal barrier disruption contribute to sustained and systemic inflammation in CKD patients