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When a GHRH analogue (such as CJC-1295 No DAC) and a GHRP (such as ipamorelin) are administered together, the combined GH release substantially exceeds the sum of the individual responses a finding consistent with the well-established physiological synergism between the hypothalamic GHRH and ghrelin systems

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Indeed, the components of this system are involved in the bi-directional transport of acyl moieties from cytosol to mitochondria and vice versa, thus playing a fundamental role in tuning the switch between the glucose and fatty acid metabolism

10.1016/j.lwt.2017.07.018 28 SunY.XuJ.ZhaoH.LiY.ZhangH.YangB.et al