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Efficacy and safety of trimetazidine after percutaneous coronary intervention (ATPCI): a randomised, double-blind, placebo-controlled trial

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Conversely, smaller studies exploring acute, peri-procedural administration, such as intravenous Vitamin C combined with E pre-PCI [PREVEC trial (Rodrigo et al., 2014)] or intracoronary Vitamin E during surgery (Canbaz et al., 2003), showed some positive signals regarding reduced infarct size or injury markers, underscoring the importance of timing and local delivery