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Sulfhydril groups present on plasma proteins can act as antioxidants by donating an electron to neutralize a free radical

This might be responsible for the low IGF-I levels seen in association with states of insulin resistance, as the metabolic syndrome[301]

nobelprize.org

doi:10.1126/science.aax3338

Prognostic Value of Melanoma-Associated Antigen-A (MAGE-A) Gene expression in various human cancers: a systematic review and Meta-analysis of 7428 patients and 44 studies