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Plasma cell differentiation is accompanied by endoplasmic reticulum enlargement, increased membrane-bound ribosomes, upregulation of endoplasmic reticulum chaperones such as BIP and GRP94, and transcription factors like XBP-1 ( Figure 3 )

Mol Cell 39(2):171183

ICAMs over-expression in endothelial cells is the initiating step for atherosclerotic plaque formation (Moss and Ramji 2016)

Further study reveal that a Fubrick tea supplement mitigated obesity induced by a HFD by altering gut microbiota and increased serum levels of caffeine, theophylline, and theobromine, correlating positively with the abundance of the Lachnospiraceae bacterial group (139)

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